User profiles for M. L. Leibowitz
Mitchell LeibowitzPostdoctoral Research Fellow, Dana-Farber Cancer Institute Verified email at virginia.edu Cited by 1665 |
Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements
Recent genome sequencing studies have identified several classes of complex genomic
rearrangements that appear to be derived from a single catastrophic event. These discoveries …
rearrangements that appear to be derived from a single catastrophic event. These discoveries …
Chromothripsis: a new mechanism for rapid karyotype evolution
Chromosomal rearrangements are generally thought to accumulate gradually over many
generations. However, DNA sequencing of cancer and congenital disorders uncovered a new …
generations. However, DNA sequencing of cancer and congenital disorders uncovered a new …
[HTML][HTML] Small but mighty: the causes and consequences of micronucleus rupture
M Kwon, ML Leibowitz, JH Lee - Experimental & molecular medicine, 2020 - nature.com
Micronuclei are small DNA-containing nuclear structures that are spatially isolated from the
main nucleus. They are frequently found in pathologies, including cancer. It was recently …
main nucleus. They are frequently found in pathologies, including cancer. It was recently …
Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing
… of cells was selected for 1 week with 12 µg ml −1 puromycin. Cells were treated with 40 nM
… the block into complete medium containing 0.5 µg ml −1 doxycycline, which was washed out …
… the block into complete medium containing 0.5 µg ml −1 doxycycline, which was washed out …
Genome-wide mapping and assembly of structural variant breakpoints in the mouse genome
…, RA Clark, S Sokolova, ML Leibowitz… - Genome …, 2010 - genome.cshlp.org
Structural variation (SV) is a rich source of genetic diversity in mammals, but due to the
challenges associated with mapping SV in complex genomes, basic questions regarding their …
challenges associated with mapping SV in complex genomes, basic questions regarding their …
[HTML][HTML] Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
Karyotype alterations have emerged as on-target complications from CRISPR-Cas9 genome
editing. However, the events that lead to these karyotypic changes in embryos after Cas9-…
editing. However, the events that lead to these karyotypic changes in embryos after Cas9-…
Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms
…, M Lindberg, GG Faust, ML Leibowitz… - Genome …, 2013 - genome.cshlp.org
Tumor genomes are generally thought to evolve through a gradual accumulation of mutations,
but the observation that extraordinarily complex rearrangements can arise through single …
but the observation that extraordinarily complex rearrangements can arise through single …
[PDF][PDF] Genome sequencing of mouse induced pluripotent stem cells reveals retroelement stability and infrequent DNA rearrangement during reprogramming
The biomedical utility of induced pluripotent stem cells (iPSCs) will be diminished if most
iPSC lines harbor deleterious genetic mutations. Recent microarray studies have shown that …
iPSC lines harbor deleterious genetic mutations. Recent microarray studies have shown that …
Total portfolio duration: a new perspective on asset allocation
ML Leibowitz - Financial Analysts Journal, 1986 - Taylor & Francis
The concept of duration has proved to be a valuable tool for gauging the sensitivity of a
bond portfolio to movements in interest rates. By balancing the duration of a fixed income …
bond portfolio to movements in interest rates. By balancing the duration of a fixed income …
A total differential approach to equity duration
ML Leibowitz, EH Sorensen, RD Arnott… - Financial Analysts …, 1989 - Taylor & Francis
Most of the risk associated with fixed income price movements is accounted for by their
duration-that is, their sensitivity to changes in the discount rate. Thus, for bonds, duration and …
duration-that is, their sensitivity to changes in the discount rate. Thus, for bonds, duration and …