[PDF][PDF] Assembly mechanism of mucin and von Willebrand factor polymers

G Javitt, L Khmelnitsky, L Albert, LS Bigman, N Elad… - Cell, 2020 - cell.com
The respiratory and intestinal tracts are exposed to physical and biological hazards
accompanying the intake of air and food. Likewise, the vasculature is threatened by inflammation …

Computational optimization of antibody humanness and stability by systematic energy-based ranking

A Tennenhouse, L Khmelnitsky, R Khalaila… - Nature biomedical …, 2024 - nature.com
… Marked are the 10 CUMAb designs (6–10 include unusual framework mutation from a),
the protein ladder (L) and the AXL protein used as input (I). c, AlphaFold model of mouse anti-…

Engineering biocatalytic systems in organic media with low water content

YL Khmelnitsky, AV Levashov, NL Klyachko… - Enzyme and Microbial …, 1988 - Elsevier
The use of organic media in biocatalysis stems from the fact that in many cases biocatalytic
processes can hardly be conducted (if at all) in aqueous solutions because of extremely low …

Micellar enzymology: its relation to membranology

…, NL Klyachko, AV Kabanov, YL Khmelnitsky… - … et Biophysica Acta (BBA …, 1989 - Elsevier
Micellar enzymology, a new trend in molecular biology, studies catalysis by enzymes entrapped
in hydrated reversed micelles composed of surfactants (phospholipids, detergents) in …

[HTML][HTML] Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces

…, R Lipsh, L Khmelnitsky… - PLoS computational …, 2019 - journals.plos.org
… Position 43 L is located in a tight turn that connects two neighboring β strands, away from
the CDRs, but Pro is not the consensus identity at this position (Ala and Ser are preferred). …

Biocatalysis in nonaqueous solvents

YL Khmelnitsky, JO Rich - Current Opinion in Chemical Biology, 1999 - Elsevier
Biotransformation technologies have enjoyed a renewed interest from researchers and industry
because of the progress made in the discovery and design of new, efficient biocatalysts …

Denaturation capacity: a new quantitative criterion for selection of organic solvents as reaction media in biocatalysis

YL Khmelnitsky, VV Mozhaev… - European Journal of …, 1991 - Wiley Online Library
The process of reversible denaturation of several proteins (α‐chymotrypsin, trypsin, laccase,
chymotrypsinogen, cytochrome c and myoglobin) by a broad series of organic solvents of …

Salts dramatically enhance activity of enzymes suspended in organic solvents

YL Khmelnitsky, SH Welch, DS Clark… - Journal of the American …, 1994 - ACS Publications
Enzymes catalyze a diverse array of reactions in nonaqueous media.* 1 However, their catalytic
activities in organic solvents are often orders of magnitude lower than those in aqueous …

Catalytic activity and denaturation of enzymes in water/organic cosolvent mixtures: α‐Chymotrypsin and laccase in mixed water/alcohol, water/glycol and water …

VV Mozhaev, YL Khmelnitsky… - European Journal of …, 1989 - Wiley Online Library
… This limitation will be eliminated by further development of the concept (Khmelnitsky, Yu. L.
et al., unpublished observations). Concluding the discussion we wish to mention recent stud…

Microwave-assisted synthesis of substituted imidazoles on a solid support under solvent-free conditions

AY Usyatinsky, YL Khmelnitsky - Tetrahedron Letters, 2000 - Elsevier
The solvent-free microwave-assisted synthesis of 2,4,5-substituted and 1,2,4,5-substituted
imidazoles is reported. Imidazoles are obtained as a result of the condensation of a 1,2-…