The field of nanotechnology may hold the promise of significant improvements in the health
and well being of patients, as well as in manufacturing technologies. The knowledge of this …

The understanding of deposition of particles in the respiratory tract is of great value to risk
assessment of inhalation toxicology and to improve efficiency in drug delivery of inhalation …

Sarcoidosis is a systemic disease of unknown etiology characterized by the presence of
noncaseating granulomas in any organ, most commonly the lungs and intrathoracic lymph …

The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is currently
believed that four to six crypt stem cells reside at the +4 position immediately above the …

The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We have
recently demonstrated the presence of about six cycling Lgr5 + stem cells at the bottoms of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus
disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs …

The study of gastric epithelial homeostasis and cancer has been hampered by the lack of
stem cell markers and in vitro culture methods. The Wnt target gene Lgr5 marks stem cells in …

Mutations of the genes encoding APC or ß-catenin in colon carcinoma induce the constitutive
formation of nuclear ß-catenin/Tcf-4 complexes, resulting in activated transcription of Tcf …

The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven
proliferative compartments. We find that conditional deletion of both genes in the mouse gut …

INTRODUCTION: Nasal cannulas are commonly used to deliver oxygen in acute and
chronic care settings; however, there are few data available on delivered fraction of inspired …