IL-17 is a cytokine that plays an important role in orchestrating innate immune function. In
addition, IL-17 has been shown to exacerbate autoimmune diseases. CD4 + αβ T cells, γδ T …

Consistent with an important role for adaptive immunity in modulating interactions between
intestinal bacteria and host, dramatic alteration in the composition of gut microbes during …

Rationale: Beryllium continues to have a wide range of industrial applications. Exposure to
beryllium can lead to sensitization (BeS) and chronic beryllium disease (CBD). Objectives: …

Rationale: Results from 16S rDNA-encoding gene sequence–based, culture-independent
techniques have led to conflicting conclusions about the composition of the lower respiratory …

Understanding gut microbiota alterations associated with HIV infection and factors that drive
these alterations may help explain gut-linked diseases prevalent with HIV. 16S rRNA …

Functional impairment of HIV-specific CD4+ T cells during chronic HIV infection is closely
linked to viral replication and thought to be due to T cell exhaustion. Programmed death 1 (PD-…

Although cigarette smoking is implicated in the pathogenesis of emphysema, the precise
mechanisms of chronic progressive alveolar septal destruction are not well understood. We …

Inflammation-induced pulmonary fibrosis (PF) leads to irreversible loss of lung function and
is a predictor of mortality in numerous lung diseases. Why some subjects with lung …

Rationale: Lung infections caused by opportunistic or virulent pathogens are a principal
cause of morbidity and mortality in HIV infection. It is unknown whether HIV infection leads to …

As of January 2022, at least 60 million individuals are estimated to develop post-acute
sequelae of SARS-CoV-2 (PASC) after infection with severe acute respiratory syndrome …