[HTML][HTML] Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans
P Sagoo, E Perucha, B Sawitzki… - The Journal of …, 2010 - Am Soc Clin Investig
Identifying transplant recipients in whom immunological tolerance is established or is developing
would allow an individually tailored approach to their posttransplantation management. …
would allow an individually tailored approach to their posttransplantation management. …
Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells
P Sagoo, N Ali, G Garg, FO Nestle, RI Lechler… - Science translational …, 2011 - science.org
Graft rejection by the immune system is a major cause of transplant failure. Lifelong
immunosuppression decreases the incidence of graft rejection; however, nonspecific …
immunosuppression decreases the incidence of graft rejection; however, nonspecific …
Inhibition of NF-κB and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells
PH Tan, P Sagoo, C Chan, JB Yates… - The Journal of …, 2005 - journals.aai.org
Dendritic cells (DCs) are central to T cell immunity, and many strategies have been used to
manipulate DCs to modify immune responses. We investigated the effects of antioxidants …
manipulate DCs to modify immune responses. We investigated the effects of antioxidants …
Dendritic cells as a tool to induce transplantation tolerance: obstacles and opportunities
…, G Lombardi, KA Gelderman, P Sagoo… - …, 2011 - journals.lww.com
Dendritic cells are the key component to regulate and coordinate adaptive immune responses,
including tolerance. This overview will briefly summarize different strategies to generate …
including tolerance. This overview will briefly summarize different strategies to generate …
Increases in greenhouse forcing inferred from the outgoing longwave radiation spectra of the Earth in 1970 and 1997
JE Harries, HE Brindley, PJ Sagoo, RJ Bantges - Nature, 2001 - nature.com
The evolution of the Earth's climate has been extensively studied 1 , 2 , and a strong link
between increases in surface temperatures and greenhouse gases has been established 3 , 4 . …
between increases in surface temperatures and greenhouse gases has been established 3 , 4 . …
[HTML][HTML] Relevance of regulatory T cell promotion of donor-specific tolerance in solid organ transplantation
P Sagoo, G Lombardi, RI Lechler - Frontiers in immunology, 2012 - frontiersin.org
Current clinical strategies to control the alloimmune response after transplantation do not fully
prevent induction of the immunological processes which lead to acute and chronic immune…
prevent induction of the immunological processes which lead to acute and chronic immune…
[HTML][HTML] Inflammatory cytokines induce apoptosis of corneal endothelium through nitric oxide
P Sagoo, G Chan, DFP Larkin… - … ophthalmology & visual …, 2004 - iovs.arvojournals.org
… No significant change in nitrite generation relative to unstimulated control cell samples
was detected in MCECs (P > 0.05) or PMCECs treated with each cytokine alone. Similarly, at …
was detected in MCECs (P > 0.05) or PMCECs treated with each cytokine alone. Similarly, at …
[HTML][HTML] Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+ CD25+ FOXP3+ T regulatory cell …
Adoptive transfer of ex vivo expanded CD4+ CD25+ FOXP3+ regulatory T cells is a successful
therapy for autoimmune diseases and transplant rejection in experimental models. In man…
therapy for autoimmune diseases and transplant rejection in experimental models. In man…
[HTML][HTML] In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity
P Sagoo, Z Garcia, B Breart, F Lemaître… - Nature medicine, 2016 - nature.com
… All statistical tests were two-tailed, and significance was defined as P < 0.05. *P < 0.05, **P
< 0.01, ***P < 0.001. No statistical test was used to predetermine sample size, and all …
< 0.01, ***P < 0.001. No statistical test was used to predetermine sample size, and all …
The transformative potential of HSC gene therapy as a genetic medicine
P Sagoo, HB Gaspar - Gene therapy, 2023 - nature.com
Hematopoietic stem cells (HSCs) are precursor cells that give rise to blood, immune and
tissue-resident progeny in humans. Their position at the starting point of hematopoiesis offers a …
tissue-resident progeny in humans. Their position at the starting point of hematopoiesis offers a …