[HTML][HTML] Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

P Sagoo, E Perucha, B Sawitzki… - The Journal of …, 2010 - Am Soc Clin Investig
Identifying transplant recipients in whom immunological tolerance is established or is developing
would allow an individually tailored approach to their posttransplantation management. …

Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells

P Sagoo, N Ali, G Garg, FO Nestle, RI Lechler… - Science translational …, 2011 - science.org
Graft rejection by the immune system is a major cause of transplant failure. Lifelong
immunosuppression decreases the incidence of graft rejection; however, nonspecific …

Inhibition of NF-κB and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells

PH Tan, P Sagoo, C Chan, JB Yates… - The Journal of …, 2005 - journals.aai.org
Dendritic cells (DCs) are central to T cell immunity, and many strategies have been used to
manipulate DCs to modify immune responses. We investigated the effects of antioxidants …

Dendritic cells as a tool to induce transplantation tolerance: obstacles and opportunities

…, G Lombardi, KA Gelderman, P Sagoo… - …, 2011 - journals.lww.com
Dendritic cells are the key component to regulate and coordinate adaptive immune responses,
including tolerance. This overview will briefly summarize different strategies to generate …

Increases in greenhouse forcing inferred from the outgoing longwave radiation spectra of the Earth in 1970 and 1997

JE Harries, HE Brindley, PJ Sagoo, RJ Bantges - Nature, 2001 - nature.com
The evolution of the Earth's climate has been extensively studied 1 , 2 , and a strong link
between increases in surface temperatures and greenhouse gases has been established 3 , 4 . …

[HTML][HTML] Relevance of regulatory T cell promotion of donor-specific tolerance in solid organ transplantation

P Sagoo, G Lombardi, RI Lechler - Frontiers in immunology, 2012 - frontiersin.org
Current clinical strategies to control the alloimmune response after transplantation do not fully
prevent induction of the immunological processes which lead to acute and chronic immune…

[HTML][HTML] Inflammatory cytokines induce apoptosis of corneal endothelium through nitric oxide

P Sagoo, G Chan, DFP Larkin… - … ophthalmology & visual …, 2004 - iovs.arvojournals.org
… No significant change in nitrite generation relative to unstimulated control cell samples
was detected in MCECs (P > 0.05) or PMCECs treated with each cytokine alone. Similarly, at …

[HTML][HTML] Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+ CD25+ FOXP3+ T regulatory cell …

…, N Ali, F Xiao, M Peakman, B Afzali, P Sagoo… - …, 2013 - ncbi.nlm.nih.gov
Adoptive transfer of ex vivo expanded CD4+ CD25+ FOXP3+ regulatory T cells is a successful
therapy for autoimmune diseases and transplant rejection in experimental models. In man…

[HTML][HTML] In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity

P Sagoo, Z Garcia, B Breart, F Lemaître… - Nature medicine, 2016 - nature.com
… All statistical tests were two-tailed, and significance was defined as P < 0.05. *P < 0.05, **P
< 0.01, ***P < 0.001. No statistical test was used to predetermine sample size, and all …

The transformative potential of HSC gene therapy as a genetic medicine

P Sagoo, HB Gaspar - Gene therapy, 2023 - nature.com
Hematopoietic stem cells (HSCs) are precursor cells that give rise to blood, immune and
tissue-resident progeny in humans. Their position at the starting point of hematopoiesis offers a …