User profiles for M. L. Leibowitz

Mitchell Leibowitz

Postdoctoral Research Fellow, Dana-Farber Cancer Institute
Verified email at virginia.edu
Cited by 1648

Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements

CZ Zhang, ML Leibowitz, D Pellman - Genes & development, 2013 - genesdev.cshlp.org
Recent genome sequencing studies have identified several classes of complex genomic
rearrangements that appear to be derived from a single catastrophic event. These discoveries …

Chromothripsis: a new mechanism for rapid karyotype evolution

ML Leibowitz, CZ Zhang, D Pellman - Annual review of genetics, 2015 - annualreviews.org
Chromosomal rearrangements are generally thought to accumulate gradually over many
generations. However, DNA sequencing of cancer and congenital disorders uncovered a new …

[HTML][HTML] Small but mighty: the causes and consequences of micronucleus rupture

M Kwon, ML Leibowitz, JH Lee - Experimental & molecular medicine, 2020 - nature.com
Micronuclei are small DNA-containing nuclear structures that are spatially isolated from the
main nucleus. They are frequently found in pathologies, including cancer. It was recently …

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

ML Leibowitz, S Papathanasiou, PA Doerfler… - Nature …, 2021 - nature.com
… of cells was selected for 1 week with 12 µg ml −1 puromycin. Cells were treated with 40 nM
… the block into complete medium containing 0.5 µg ml −1 doxycycline, which was washed out …

Genome-wide mapping and assembly of structural variant breakpoints in the mouse genome

…, RA Clark, S Sokolova, ML Leibowitz… - Genome …, 2010 - genome.cshlp.org
Structural variation (SV) is a rich source of genetic diversity in mammals, but due to the
challenges associated with mapping SV in complex genomes, basic questions regarding their …

[HTML][HTML] Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

…, S Markoulaki, LJ Blaine, ML Leibowitz… - Nature …, 2021 - nature.com
Karyotype alterations have emerged as on-target complications from CRISPR-Cas9 genome
editing. However, the events that lead to these karyotypic changes in embryos after Cas9-…

Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms

…, M Lindberg, GG Faust, ML Leibowitz… - Genome …, 2013 - genome.cshlp.org
Tumor genomes are generally thought to evolve through a gradual accumulation of mutations,
but the observation that extraordinarily complex rearrangements can arise through single …

[PDF][PDF] Genome sequencing of mouse induced pluripotent stem cells reveals retroelement stability and infrequent DNA rearrangement during reprogramming

AR Quinlan, MJ Boland, ML Leibowitz, S Shumilina… - Cell stem cell, 2011 - cell.com
The biomedical utility of induced pluripotent stem cells (iPSCs) will be diminished if most
iPSC lines harbor deleterious genetic mutations. Recent microarray studies have shown that …

Total portfolio duration: a new perspective on asset allocation

ML Leibowitz - Financial Analysts Journal, 1986 - Taylor & Francis
The concept of duration has proved to be a valuable tool for gauging the sensitivity of a
bond portfolio to movements in interest rates. By balancing the duration of a fixed income …

A total differential approach to equity duration

ML Leibowitz, EH Sorensen, RD Arnott… - Financial Analysts …, 1989 - Taylor & Francis
Most of the risk associated with fixed income price movements is accounted for by their
duration-that is, their sensitivity to changes in the discount rate. Thus, for bonds, duration and …