COVID-19: challenges of viral variants
JL Jacobs, G Haidar, JW Mellors - Annual Review of Medicine, 2023 - annualreviews.org
The COVID-19 pandemic has been accompanied by SARS-CoV-2 evolution and emergence
of viral variants that have far exceeded initial expectations. Five major variants of concern (…
of viral variants that have far exceeded initial expectations. Five major variants of concern (…
Mechanisms of MAVS regulation at the mitochondrial membrane
JL Jacobs, CB Coyne - Journal of molecular biology, 2013 - Elsevier
Mitochondria have emerged as critical platforms for antiviral innate immune signaling. This
is due in large part to the mitochondrial localization of the innate immune signaling adaptor …
is due in large part to the mitochondrial localization of the innate immune signaling adaptor …
[HTML][HTML] The impact of plant phytochemicals on the gut microbiota of humans for a balanced life
The gastrointestinal tract of humans is a complex microbial ecosystem known as gut microbiota.
The microbiota is involved in several critical physiological processes such as digestion, …
The microbiota is involved in several critical physiological processes such as digestion, …
The role of psychiatric disorders in predicting drug dependence treatment outcomes
WM Compton III, LB Cottler, JL Jacobs… - American Journal of …, 2003 - Am Psychiatric Assoc
OBJECTIVE: Previous research has demonstrated that psychiatric disorders are common
among people who abuse alcohol and drugs, but few studies have examined the relationship …
among people who abuse alcohol and drugs, but few studies have examined the relationship …
The emerging plasticity of SARS-CoV-2
KD McCormick, JL Jacobs, JW Mellors - Science, 2021 - science.org
Viruses evolve as a result of mutation (misincorporations, insertions or deletions, and
recombination) and natural selection for favorable traits such as more efficient viral replication, …
recombination) and natural selection for favorable traits such as more efficient viral replication, …
[HTML][HTML] Grape marc reduces methane emissions when fed to dairy cows
Grape marc (the skins, seeds, stalk, and stems remaining after grapes have been pressed
to make wine) is currently a by-product used as a feed supplement by the dairy and beef …
to make wine) is currently a by-product used as a feed supplement by the dairy and beef …
Overexpression of the 14α-Demethylase Target Gene (CYP51) Mediates Fungicide Resistance in Blumeriella jaapii
Z Ma, TJ Proffer, JL Jacobs… - Applied and …, 2006 - Am Soc Microbiol
Sterol demethylation inhibitor (DMI) fungicides are widely used to control fungi pathogenic
to humans and plants. Resistance to DMIs is mediated either through alterations in the …
to humans and plants. Resistance to DMIs is mediated either through alterations in the …
[HTML][HTML] A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal
A wide range of RNA viruses use programmed −1 ribosomal frameshifting for the production
of viral fusion proteins. Inspection of the overlap regions between ORF1a and ORF1b of the …
of viral fusion proteins. Inspection of the overlap regions between ORF1a and ORF1b of the …
Effect of solar UV-B radiation on a phyllosphere bacterial community
JL Jacobs, GW Sundin - Applied and Environmental Microbiology, 2001 - Am Soc Microbiol
The effect of solar UV-B radiation on the population dynamics and composition of the culturable
bacterial community from peanut (Arachishypogeae L.) was examined in field studies …
bacterial community from peanut (Arachishypogeae L.) was examined in field studies …
[HTML][HTML] SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization
…, BR Treat, PM Da Silva Castanha, JL Jacobs… - Nature …, 2022 - nature.com
Mutations in the spike glycoproteins of SARS-CoV-2 variants of concern have independently
been shown to enhance aspects of spike protein fitness. Here, we describe an antibody …
been shown to enhance aspects of spike protein fitness. Here, we describe an antibody …