User profiles for B. Leonard

Brian M Leonard

University of Wyoming
Verified email at uwyo.edu
Cited by 3793

The olfactory bulbectomized rat as a model of depression: an update

JP Kelly, AS Wrynn, BE Leonard - Pharmacology & therapeutics, 1997 - Elsevier
The olfactory bulbectomized (OB) rat has been proposed as an animal model of depression.
The following behavioural changes have been observed following bilateral olfactory …

Depression, stress and immunological activation: the role of cytokines in depressive disorders

TJ Connor, BE Leonard - Life sciences, 1998 - Elsevier
Traditionally, both stress and depression have been associated with impaired immune function
and increased susceptibility to infectious and neoplastic disease. However over the last …

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a …

B Leonard, M Maes - Neuroscience & Biobehavioral Reviews, 2012 - Elsevier
This paper reviews that cell-mediated-immune (CMI) activation and inflammation contribute
to depressive symptoms, including anhedonia; anxiety-like behaviors; fatigue and somatic …

A stable and accurate convective modelling procedure based on quadratic upstream interpolation

BP Leonard - Computer methods in applied mechanics and …, 1979 - Elsevier
A convective modelling procedure is presented which avoids the stability problems of central
differencing while remaining free of the inaccuracies of numerical diffusion associated with …

How should we define health?

…, H Van Der Horst, AR Jadad, D Kromhout, B Leonard… - Bmj, 2011 - bmj.com
The WHO definition of health as complete wellbeing is no longer fit for purpose given the
rise of chronic disease. Machteld Huber and colleagues propose changing the emphasis …

The ULTIMATE conservative difference scheme applied to unsteady one-dimensional advection

BP Leonard - Computer methods in applied mechanics and …, 1991 - Elsevier
… (b) Exact solution after translating 45 Ax to the right. … but the normalized ~b I will still depend
most strongly on 4)[. … ); in the Sweby diagram (see Appendix B) the function forms portion of a …

Simple high‐accuracy resolution program for convective modelling of discontinuities

BP Leonard - International journal for numerical methods in …, 1988 - Wiley Online Library
… Figure l(b) shows the same information in terms of the locally normalized variable … The
corresponding normalized interpolations are shown in Figure 2(b) for a specific value of &( <0-5). …

APOBEC3B is an enzymatic source of mutation in breast cancer

…, MA Carpenter, A Rathore, AM Land, B Leonard… - Nature, 2013 - nature.com
Several mutations are required for cancer development, and genome sequencing has revealed
that many cancers, including breast cancer, have somatic mutation spectra dominated …

Multiple phases of molybdenum carbide as electrocatalysts for the hydrogen evolution reaction

C Wan, YN Regmi, BM Leonard - Angewandte Chemie, 2014 - Wiley Online Library
… p-Phenylenediamine (pPDA) was used as the precursor to produce η-MoC (Figure 1 b) at
1050 C with zero dwell time. FeCl 3 was mixed with the amine–metal oxide to help stabilize …

Interactions between location and task affect the spatial and directional firing of hippocampal neurons

EJ Markus, YL Qin, B Leonard, WE Skaggs… - Journal of …, 1995 - Soc Neuroscience
… First half of the random task (a), second half of the random task (b), first half of the directed
task (c), second half of the directed task (d). A and B depict the data from the circular platform, …